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KMID : 0370220240680010001
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Yakhak Hoeji
2024 Volume.68 No. 1 p.1 ~ p.9
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Review on the Synthesis and Biological Activities of Acrolein and Its Acetal Form
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Cho Eun-Kang
Kim Ye-Eun
Lee Sang-Hyup
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Abstract
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Acrolein (2-propenal) is the simplest α,β-unsaturated aldehyde. Humans are exposed to acrolein by smoking,burning woods, oil or fats in meats and vegetables, and by endogenous formation through lipid peroxidation. Acrolein isa highly electrophilic molecule, and readily reacts with nucleophilic biomolecules such as peptides, proteins, and nucleicacids. This high reactivity causes acrolein to have detrimental effects on human or bacteria. The syntheses of acrolein fromseveral starting materials were described. Additionally, several acrolein derivatives and their synthetic process weredescribed with particular emphasis on the acetal forms of acrolein. It is suggested that acrolein and its acetal forms needto be further investigated for medicinal properties.
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KEYWORD
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Acrolein, Acrolein acetal form, Aldehyde, Antibacterial
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